Investigation by Microarray Analysis of the Immunostimulatory Function of an Extract of the Genus Plant Salacia in
نویسندگان
چکیده
In our previous studies, Salacia extracts demonstrated beneficial effects on the enteric environment of the rat, as represented by decrease in ammonia and other products decomposed by enteric microorganism. In the present study, we showed that the expression of immunologically relevant genes increased in the epithelium of the small intestine from the rat orally dosed with Salacia extracts. T-RFLP analysis (Nagashima method) revealed altered composition of intestinal flora. Salacia extracts reportedly inhibit enzymatic degradation of polysaccharides, hence blocking the intestinal absorption of polysaccharides. These results taken together suggested that unabsorbed polysaccharides may affect the intestinal flora environment through the enteric immune system of the rat.
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